PeptideSynthetics: Peptide Protein Research Ltd.

Peptide modifications

The following is a list of peptide modifications we have performed over the last 12 months.

Modifications at the N-terminus

  • Acetyl
  • Biotin
  • Fluorescein (FAM, FITC)
  • TAMRA
  • Cy dyes (Cy3, Cy5 etc)
  • Alexa fluor dyes
  • Benzyloxycarbonyl (CBZ) (Z)
  • Pyroglutamic acid (Pyr)
  • Octanoic acid
  • Glycolic acid
  • t-butoxycarbonyl (Boc)
  • Fluorenylmethoxycarbonyl (Fmoc)
  • Rhodamine110
  • Benzoic acid
  • PEGylation
  • Myristic acid

Modifications at the C-terminus

  • Alcohol
  • Aldehyde
  • Amide
  • Methyl ester
  • Methyl amide
  • Ethyl amide
  • Biotin (Lys or Cys side chain)
  • Benzaldehyde (Lys side chain)
  • Fluorescein (Lys side chain)
  • TAMRA (Lys side chain)
  • Cy dyes (Lys side chain)
  • pNA
  • Farnesyl (Cys side chain)

Unnatural amino acids

  • Acetyl-lysine
  • Amino hexanonic acid (Ahx)
  • Amino isobutyric acid (Aib)
  • Amino benzoic acid
  • Beta alanine
  • Citrulline (Cit)
  • Cyclohexylalanine (Cha)
  • Cyclohexylglycine (Chg)
  • D amino acids
  • Methyl Lysine
  • Dimethyl Lysine
  • Trimethyl Lysine
  • Methyl Arginine
  • Dimethyl Arginine (Symmetric)
  • Dimethyl Arginine (Asymmetric)
  • Isotopically labeled amino acids (D, 13C, 15N)
  • Phospho Ser, Thr, Tyr
  • Napthylalanine (Nal)
  • Gamma amino butyric acid (GABA)
  • Indanylglycine
  • Hydroxyproline (Hyp)
  • N-methyl amino acids
  • Norleucine (Nle)
  • Norvaline (Nva)
  • Fluoro-Phe
  • Phenylglycine (Phg)

Other peptide modifications

  • Conjugation to KLH, BSA Ova
  • Cyclisation (head to tail, side chain, disulfide)
  • Peptides anchored to controlled pore glass (CPG)

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